Crystal Structure of a Statin Bound to a Class II Hydroxymethylglutaryl-CoA Reductase
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چکیده
منابع مشابه
Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity.
While statins, hydroxymethylglutaryl-coenzyme A reductase (HMGCR) inhibitors, are clinically proven to reduce plasma cholesterol levels, a wide variation in inter-individual response to statin therapy has been observed. Pharmacogenetic studies have identified multiple loci that potentially contribute towards the statin response, including the HMGCR gene. To examine, if a statin-resistant, catal...
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In the present paper, we prove that if L is a nilpotent Lie algebra whose proper subalge- bras are all nilpotent of class at most n, then the class of L is at most bnd=(d 1)c, where b c denotes the integral part and d is the minimal number of generators of L.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m213006200